ALERT

In Observance of U.S. holiday, Independence Day, Agilent CrossLab, iLab Operations Software will be closed during U.S. hours and have support during EU and APAC hours on Monday July 3rd and Tuesday July 4th, 2017. We will resume U.S. support hours on Wednesday July 5th, 2017. For urgent matters, please add "Urgent" to the ticket subject and we will prioritize those requests first.

 

Thank You!

Zebrafish Core

Overview

Zebrafish is a powerful system for studies of embryogenesis and to investigate mechanisms underlying human diseases.  The zebrafish is particularly well suited to study complex and acquired diseases and to identify new disease genes owing to its genetic tractability, transparency of the organism, and the ease of conducting chemical screens to identify diagnostic and potential therapeutic targets. Moreover, the high degree of genetic conservation renders translation between fish and mammals a possibility. For example, this model system can be used to validate and characterize genome-wide association study (GWAS) candidates through gain of function and loss of function approaches. For loss of function analysis the candidate, the gene of interest can be transiently knocked down or stable mutant alleles can be generated through reverse genetic mutagenesis approaches. The phenotypes produced by the normal and mutant versions can provide an indication of the gene’s function in development and disease.   The Einstein Zebrafish Core was established to facilitate this type of analysis.

Services

  • Importing and maintenance of transgenic or mutant lines
  • Fertilized wild type embryos for injection
  • Provision of fixed embryos suitable for RNA in situ hybridization, histological, or immunohistological analyses

Leadership

Teresa V. Bowman, Ph.D.
Scientific Director

Location and hours of operation

Hours  Location

M-F, 9-5    

Chanin 523

Links and Resources

  1. Core Website
  2. Facility Manual
  3. Morning and Weekend Baby/Juvenile Shrimp
  4. Brine Shrimp Recipe
  5. Protocols

Contacts

Name Role Phone Email Location
Clinton Depaolo, M.S.
Operations Director
 
718-430-4210
 
clinton.depaolo@einstein.yu.edu
 
Chanin 523
 

Service list


Search available services:
Name Description Price
100 fertilized wild type embryos Inquire
50 fixed embryos suitable for RNA in situ hybridization or immunohistological analysis Inquire
Fish Fin Clip + Genotyping (per 50 fish and more than 200 fish) Inquire
Fish Fin Clip + Genotyping (per 50 fish and up to 200 fish) Inquire
Fish Fin Clips (per 100) Inquire
Fish Fin Clips (per 50) Inquire
Genotyping (per 100) Inquire
Genotyping (per 50) Inquire
Import a mutant fish line Inquire
Microinjection service Inquire
Microinjection training Inquire

Available Equipment and Resources

Name Price
Weekend Feeder Schedule View calendar