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| Biomarkers are playing an increasingly important role in clinical and translational research, especially as we |
| move toward an era of personalized medicine in both the prevention and treatment of disease. The Biomarker |
| Analytic Research Core (BARC) — the central laboratory for the ICTR and the Biorepository — provides sophisticated tools and expertise for Einstein and Montefiore investigators from the initial planning stage through analysis and data output. |
| The services include |
| • State-of-the-art mass spectrometry analysis, in particular stable isotopes, as well as research-grade |
| determination of lipids, and metabolic markers for a variety of human subjects and animal model projects, |
| • High-throughput robotics for semiautomated high-quality sample preparation and analysis by immunoassay and liquid chromatography–mass spectrometry (LC/MS), |
| • Support for novel developmental projects featuring applications of LC/MS and two-site bead-based assays, |
| • Research-quality analysis of metabolites for human and animal samples using an Olympus AU400 autoanalyzer, and |
| • advanced training in analytical chemistry. |
| In addition to its isotope dilution LC/MS assays, BARC has already validated and made available quantitative measurement of 25(OH) Vitamin D, testosterone, and androstenedione via LC/MS. Other dual-use assays for steroids are under development, including ultrahigh sensitivity salivary cortisol, estradiol, and progesterone which will support both clinical care and research use. BARC also offers a novel method for LC/MS measurement of C-peptide, and is currently the reference lab for an ongoing clinical trial measuring insulin secretion. |
| All samples processed are labeled with barcoded cryolabels for easy identification. Records of samples and |
| data are seamlessly integrated and tracked, and are remotely accessible via a secure research database. |
Scientific Director
Dr. Matthew Abramowitz
Matthew.Abramowitz@einsteinmed.edu
718-430-8566
| Hours | Locations | ||||
|
Mon - Fri |
|
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Matthew K. Abramowitz, M.D., M.S. |
Scientific Director
|
718.430.8566
|
matthew.abramowitz@einsteinmed.edu
|
|
| Jeff Lafleur |
Operations Director
|
718.430.3314
|
jeff.lafleur@einsteinmed.edu
|
|
| Alcia Garnett |
Technician B
|
718.430.3540
|
alcia.garnett@einsteinmed.edu
|
| Service list |
| ► RIA and ELISA list (18) | |||
| Name | Description | Price | |
|---|---|---|---|
| A2 Macroglobulin ELISA, Human | Inquire | ||
| CK 18 (M65) ELISA, Human | Inquire | ||
| CK 18 Frag (M30) ELISA, Human | Inquire | ||
| DHEAS ELISA, Human | Inquire | ||
| Follicle Stimulating Hormone, human |
FSH ELISA Lab requires 60ul serum |
||
| Hyaluronic Acid ELISA, Human | Inquire | ||
| IL-1 beta, high sensitivity, Human ELISA |
ELISA, Human Lab requires 210ul serum/plasma |
||
| Insulin, rodent Chemiluminescence ELISA |
Lab requires 15ul Serum/Plasma |
||
| Leptin Receptor, Human ELISA | Inquire | ||
| Luteinizing Hormone (LH) ELISA |
Lab requires 60ul serum |
||
| NGAL ELISA |
The neutrofil gelatinase-associated lipocalin (NGAL) ELISA has been validated for human urine. Lab requires 25ul urine |
Inquire | |
| Pepsinogen I, Human ELISA | Inquire | ||
| Pepsinogen II, Human ELISA | Inquire | ||
| Proinsulin, Human RIA | Inquire | ||
| sRAGE, Human ELISA |
Soluble form of receptor for advanced glycation end-products. Serum or plasma - 125 µL needed |
||
| TIMP-1, Human ELISA | Inquire | ||
| Tissue Factor, Human ELISA | Inquire | ||
| VEGF, Human ELISA | Inquire | ||
| ► Archived (3) | |||
| Name | Description | Price | |
| Androstenedione, LCMS | Inquire | ||
| Short term storage- non industry/ per vial | Inquire | ||
| Testosterone, LCMS | Inquire | ||
| ► Sample Processing (7) | |||
| Name | Description | Price | |
| CSF | Inquire | ||
| CSF Pellet | Inquire | ||
| CSF SUP | Inquire | ||
| External Sample Processing | Inquire | ||
| Industry Sample shipping prep | Inquire | ||
| Red blood cell pellet |
Collected after centrifugation and removal of supernatant. |
||
| Sample tracking | |||
| ► Other Services (2) | |||
| Name | Description | Price | |
| Protease inhibitor tubes | |||
| Short-term storage |
Per participant for industry-sponsored studies |
Inquire | |
