Biomarker Analytic Research Core (BARC)

Overview of Services

Biomarkers are playing an increasingly important role in clinical and translational research, especially as we 
move toward an era of personalized medicine in both the prevention and treatment of disease. The Biomarker
Analytic Research Core (BARC) — the central laboratory for the ICTR and the Biorepository — provides sophisticated tools and expertise for Einstein and Montefiore investigators from the initial planning stage through analysis and data output. 
The services include
State-of-the-art mass spectrometry analysis, in particular stable isotopes, as well as research-grade
determination of lipids, and metabolic markers for a variety of human subjects and animal model projects,
High-throughput robotics for semiautomated high-quality sample preparation and analysis by immunoassay and liquid chromatography–mass spectrometry (LC/MS),
Support for novel developmental projects featuring applications of LC/MS and two-site bead-based assays,
Research-quality analysis of metabolites for human and animal samples using an Olympus AU400 autoanalyzer, and
advanced training in analytical chemistry.
In addition to its isotope dilution LC/MS assays, BARC has already validated and made available quantitative measurement of 25(OH) Vitamin D, testosterone, and androstenedione via LC/MS. Other dual-use assays for steroids are under development, including ultrahigh sensitivity salivary cortisol, estradiol, and progesterone which will support both clinical care and research use. BARC also offers a novel method for LC/MS measurement of C-peptide, and is currently the reference lab for an ongoing clinical trial measuring insulin secretion.
All samples processed are labeled with barcoded cryolabels for easy identification. Records of samples and
data are seamlessly integrated and tracked, and are remotely accessible via a secure research database.


Scientific Director
Daniel Stein, M.D.

Scientific Director
Norman Fleischer, M.D.

Operations Director
Nicole Bjorklund, Ph.D.


Location and hours of operation

Hours Locations

Mon - Fri    
9 - 5

1300 Morris Park Avenue 111 East 210th Street
Bronx, NY 10461 Bronx, NY 10467

Links and Resources

  1. Our Website
  2. Assay List
  3. ICTR Services


Name Role Phone Email Location
Daniel Stein, M.D.
Scientific Director

Norman Fleischer, M.D.
Scientific Director

Nicole Bjorklund, Ph.D.
Operations Director



Name Description
Sample Analysis 

This includes all routine laboratory chemistries, immunoassays, GCMS and LCMS.

To view a list of all available sample analysis assays, please click here.


Sample Processing 

Processing of samples includes following study-specific protocols such as incubation, centrifugation, etc.  Processed samples are aliquoted into proper cryopreservation containers and labeled.  The samples can then be shipped out, delivered to an Einstein laboratory or sent to the biorepository.  Ordering testing from Montefiore Medical Center Pathology Department is also available along with courier service

Equipment Training Request   
Androstenedione, LCMS   
Follicle Stimulating Hormone, human 


IL-1 beta, high sensitivity 

ELISA, Human

Insulin, rodent  

ELISA using chemiluminescence

Lab requires 15ul Serum/Plasma

Luteinizing Hormone 



The neutrofil gelatinase-associated lipocalin (NGAL) ELISA has been validated for human urine.

Lab requires 25ul urine

Red blood cell pellet 

Collected after centrifugation and removal of supernatant.

Sample tracking   
Short-term storage 

Per participant for industry-sponsored studies


Soluble form of receptor for advanced glycation end-products.

Serum or plasma -  125 µL needed

Testosterone, LCMS   

Service list

Search available services: View: by category alphabetically
Sample Analysis (8)
Sample Processing (1)
Other Services (1)
Sample Processing (1)


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