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In Observance of U.S. holiday, Independence Day, Agilent CrossLab, iLab Operations Software will be closed during U.S. hours and have support during EU and APAC hours on Monday July 3rd and Tuesday July 4th, 2017. We will resume U.S. support hours on Wednesday July 5th, 2017. For urgent matters, please add "Urgent" to the ticket subject and we will prioritize those requests first.

 

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Gene Targeting/Gene Modification/Transgenic Mouse

Overview of Services

Gene Modification
The Gene Modification Facility is offering services for gene modification in cell lines and in conjunction with the Gene Targeting and Transgenic Mouse Facilities for the complete generation of gene targeted mouse lines including the generation of conventional gene knockouts, conditional knockouts, knock-in mutations and the generation of tagged proteins by conventional homologous recombination based gene targeting strategies or CRISPR (clustered regularly interspaced short palindromic repeats)-mediated gene targeting strategies. CRISPR can shorten the time frame of gene targeted mouse production remarkably and the gene targeted mice can be generated as fast as 2-4 months. Services for each individual step involved in the generation of gene targeted mouse lines are also offered.

Gene Targeting
The Gene Targeting Facility is a centralized facility for the production of gene-targeted mice. The services provided by the facility allow researchers to modify the mouse genome through methods of gene targeting or BAC transgenesis in embryonic stem (ES) cells and to introduce these changes into the mouse genome by the generation of targeted ES cells and chimeric mice. The facility also works in conjunction with the Gene Modification Facility to generate knockout mice.

Transgenic Mouse
The Transgenic Mouse Facility trains and assists Einstein investigators in the production and characterization of transgenic mouse strains. The personnel have more than a decade of experience providing high-quality service with minimal waiting times. The facility offers a wide array of mouse embryo-based services for the college, including traditional pronuclear and lentiviral injections as well as consulting, construct design and screening strategies.

Leadership

Scientific Director
Winfried Edelmann, PhD
718.678.1086
winfried.edelmann@einstein.yu.edu

Location and hours of operation

Gene Modification Gene Targeting Transgenic Mouse
Hours: Monday - Friday 9:00 AM - 5:00 PM Hours: Monday - Friday 9:00 AM - 5:00 PM Hours: Monday - Friday 9:00 AM - 5:00 PM
Location: Price 269

Location: Price Center/Block Research

Pavillion 269

Location: Price Center/Block Research Pavillion B110

Links and Resources

Contacts

Name Role Phone Email Location
Yongwei Zhang, PhD
Gene Modification Operations Director
 
718.678.1087
 
yongwei.zhang@einstein.yu.edu
 

 
Harry Hou
Gene Targeting Operations Director
 
718.678.1221, 718.678.1087
 
harry.hou@einstein.yu.edu
 
Price Center, Room B110
 
Ken Chen, M.D.
Transgenic Mouse Operations Director
 
718.678.1106
 
ken.chen@einstein.yu.edu
 
Price Center, Room B110
 

Services (Price List)


Search available services: View: by category alphabetically
CRISPR/Cas Services (9)
CRISPR Cell Line Services (8)
Conventional Gene Targeting Services (Complete Services) (5)
Gene Targeting (8)
Transgenic Mouse Services (16)
Archived Services (12)