Gene Targeting/Gene Modification/Transgenic Mouse

Overview of Services

Gene Modification
The Gene Modification Facility is offering services for gene modification in cell lines and in conjunction with the Gene Targeting and Transgenic Mouse Facilities for the complete generation of gene targeted mouse lines including the generation of conventional gene knockouts, conditional knockouts, knock-in mutations and the generation of tagged proteins by conventional homologous recombination based gene targeting strategies or CRISPR (clustered regularly interspaced short palindromic repeats)-mediated gene targeting strategies. CRISPR can shorten the time frame of gene targeted mouse production remarkably and the gene targeted mice can be generated as fast as 2-4 months. Services for each individual step involved in the generation of gene targeted mouse lines are also offered.

Gene Targeting
The Gene Targeting Facility is a centralized facility for the production of gene-targeted mice. The services provided by the facility allow researchers to modify the mouse genome through methods of gene targeting or BAC transgenesis in embryonic stem (ES) cells and to introduce these changes into the mouse genome by the generation of targeted ES cells and chimeric mice. The facility also works in conjunction with the Gene Modification Facility to generate knockout mice.

Transgenic Mouse
The Transgenic Mouse Facility trains and assists Einstein investigators in the production and characterization of transgenic mouse strains. The personnel have more than a decade of experience providing high-quality service with minimal waiting times. The facility offers a wide array of mouse embryo-based services for the college, including traditional pronuclear and lentiviral injections as well as consulting, construct design and screening strategies.


Scientific Director
Winfried Edelmann, PhD

Location and hours of operation

Gene Modification Gene Targeting Transgenic Mouse
Hours: Monday - Friday 9:00 AM - 5:00 PM Hours: Monday - Friday 9:00 AM - 5:00 PM Hours: Monday - Friday 9:00 AM - 5:00 PM
Location: Price 269

Location: Price Center/Block Research

Pavillion 269

Location: Price Center/Block Research Pavillion B110

Links and Resources


Name Role Phone Email Location
Yongwei Zhang, PhD
Gene Modification Operations Director

Gene Targeting Operations Director
718.678.1221, 718.678.1087

Price Center, Room B110
Ken Chen, M.D.
Transgenic Mouse Operations Director
Price Center, Room B110

Services (Price List)

Search available services: View: by category alphabetically
CRISPR/Cas Services (8)
CRISPR Cell Line Services (7)
Conventional Gene Targeting Services (Complete Services) (5)
Gene Targeting (9)
Transgenic Mouse Services (16)
Archived Services (14)